On the Use of Kernel Bypass Mechanisms for High-Performance Inter-container Communications

In this paper, we perform a comparison among a number of different virtual bridging and switching technologies, each widely available and commonly used on Linux, to provide network connectivity to co-located LXC containers for high-performance application scenarios

Implementation and Deployment of a Server at the Edge Using OpenStack Components

As the 5th telecommunication Generation (5G) deployments are spreading around via various mobile operators, the capabilities behind 5G are becoming more and more understandable. Infrastructure vendors, operators, and end users now have a clear picture of the 5G potential and, for that reason, the research and the development of 5G are surely continuing. The one-to-one mapping between 5G and Software Defined Network - Network Function Virtualization (SDN-NFV) architecture is not in discussion, but the impact of porting SDN-NFV into the Radio Access Network (RAN) is still under investigation. Sometimes, the RAN requirements set strong limitations even in the basic hardware and software setup. For example, the most complete and very well integrated SDN-NFV infrastructure distributions require specific hardware capabilities in terms of available nodes, in contrast with the RAN requirement to be economic, power consumption limited and with limited overhead due to operating system and middleware cost. For that reason, this study uses only a minimal set of OpenStack components in order to evaluate what is the minimal hardware capability needed to set up a basic, but fully working environment for NFV, highlighting the pros and cons of embracing a solution solely based on standard OpenStack components

Temporal Isolation Among LTE/5G Network Functions by Real-time Scheduling

Radio access networks for future LTE/5G scenarios need to be designed so as to satisfy increasingly stringent requirements in terms of overall capacity, individual user performance, flexibility and power efficiency. This is triggering a major shift in the Telcom industry from statically sized, physically provisioned network appliances towards the use of virtualized network functions that can be elastically deployed within a flexible private cloud of network operators. However, a major issue in delivering strong QoS levels is the one to keep in check the temporal interferences among co-located services, as they compete in accessing shared physical resources. In this paper, this problem is tackled by proposing a solution making use of a real-time scheduler with strong temporal isolation guarantees at the OS/kernel level. This allows for the development of a mathematical model linking major parameters of the system configuration and input traffic characterization with the achieved performance and response-time probabilistic distribution. The model is verified through extensive experiments made on Linux on a synthetic benchmark tuned according to data from a real LTE packet processing scenario

Strong Temporal Isolation among Containers in OpenStack for NFV Services

In this paper, the problem of temporal isolation among containerized software components running in shared cloud infrastructures is tackled, proposing an approach based on hierarchical real-time CPU scheduling. This allows for reserving a precise share of the available computing power for each container deployed in a multi-core server, so to provide it with a stable performance, independently from the load of other co-located containers. The proposed technique enables the use of reliable modeling techniques for end-to-end service chains that are effective in controlling the application-level performance. An implementation of the technique within the well-known OpenStack cloud orchestration software is presented, focusing on a use-case framed in the context of network function virtualization. The modified OpenStack is capable of leveraging the special real-time scheduling features made available in the underlying Linux operating system through a patch to the in-kernel process scheduler. The effectiveness of the technique is validated by gathering performance data from two applications running in a real test-bed with the mentioned modifications to OpenStack and the Linux kernel. A performance model is developed that tightly models the application behavior under a variety of conditions. Extensive experimentation shows that the proposed mechanism is successful in guaranteeing isolation of individual containerized activities on the platform

Off-label long acting injectable antipsychotics in real-world clinical practice: a cross-sectional analysis of prescriptive patterns from the STAR Network DEPOT study

Introduction Information on the off-label use of Long-Acting Injectable (LAI) antipsychotics in the real world is lacking. In this study, we aimed to identify the sociodemographic and clinical features of patients treated with on- vs off-label LAIs and predictors of off-label First- or Second-Generation Antipsychotic (FGA vs. SGA) LAI choice in everyday clinical practice. Method In a naturalistic national cohort of 449 patients who initiated LAI treatment in the STAR Network Depot Study, two groups were identified based on off- or on-label prescriptions. A multivariate logistic regression analysis was used to test several clinically relevant variables and identify those associated with the choice of FGA vs SGA prescription in the off-label group. Results SGA LAIs were more commonly prescribed in everyday practice, without significant differences in their on- and off-label use. Approximately 1 in 4 patients received an off-label prescription. In the off-label group, the most frequent diagnoses were bipolar disorder (67.5%) or any personality disorder (23.7%). FGA vs SGA LAI choice was significantly associated with BPRS thought disorder (OR = 1.22, CI95% 1.04 to 1.43, p = 0.015) and hostility/suspiciousness (OR = 0.83, CI95% 0.71 to 0.97, p = 0.017) dimensions. The likelihood of receiving an SGA LAI grew steadily with the increase of the BPRS thought disturbance score. Conversely, a preference towards prescribing an FGA was observed with higher scores at the BPRS hostility/suspiciousness subscale. Conclusion Our study is the first to identify predictors of FGA vs SGA choice in patients treated with off-label LAI antipsychotics. Demographic characteristics, i.e. age, sex, and substance/alcohol use co-morbidities did not appear to influence the choice towards FGAs or SGAs. Despite a lack of evidence, clinicians tend to favour FGA over SGA LAIs in bipolar or personality disorder patients with relevant hostility. Further research is needed to evaluate treatment adherence and clinical effectiveness of these prescriptive patterns

The Role of Attitudes Toward Medication and Treatment Adherence in the Clinical Response to LAIs: Findings From the STAR Network Depot Study

Background: Long-acting injectable (LAI) antipsychotics are efficacious in managing psychotic symptoms in people affected by severe mental disorders, such as schizophrenia and bipolar disorder. The present study aimed to investigate whether attitude toward treatment and treatment adherence represent predictors of symptoms changes over time. Methods: The STAR Network \u201cDepot Study\u201d was a naturalistic, multicenter, observational, prospective study that enrolled people initiating a LAI without restrictions on diagnosis, clinical severity or setting. Participants from 32 Italian centers were assessed at three time points: baseline, 6-month, and 12-month follow-up. Psychopathological symptoms, attitude toward medication and treatment adherence were measured using the Brief Psychiatric Rating Scale (BPRS), the Drug Attitude Inventory (DAI-10) and the Kemp's 7-point scale, respectively. Linear mixed-effects models were used to evaluate whether attitude toward medication and treatment adherence independently predicted symptoms changes over time. Analyses were conducted on the overall sample and then stratified according to the baseline severity (BPRS < 41 or BPRS 65 41). Results: We included 461 participants of which 276 were males. The majority of participants had received a primary diagnosis of a schizophrenia spectrum disorder (71.80%) and initiated a treatment with a second-generation LAI (69.63%). BPRS, DAI-10, and Kemp's scale scores improved over time. Six linear regressions\u2014conducted considering the outcome and predictors at baseline, 6-month, and 12-month follow-up independently\u2014showed that both DAI-10 and Kemp's scale negatively associated with BPRS scores at the three considered time points. Linear mixed-effects models conducted on the overall sample did not show any significant association between attitude toward medication or treatment adherence and changes in psychiatric symptoms over time. However, after stratification according to baseline severity, we found that both DAI-10 and Kemp's scale negatively predicted changes in BPRS scores at 12-month follow-up regardless of baseline severity. The association at 6-month follow-up was confirmed only in the group with moderate or severe symptoms at baseline. Conclusion: Our findings corroborate the importance of improving the quality of relationship between clinicians and patients. Shared decision making and thorough discussions about benefits and side effects may improve the outcome in patients with severe mental disorders

Virtual Network Functions as Real-time Containers in Private Clouds

This paper presents preliminary results from our on-going research for ensuring stable performance of co-located distributed cloud services in a resource-efficient way. It is based on using a real-time CPU scheduling policy to achieve a fine-grain control of the temporal interferences among real-time services running in co-located containers. We present results obtained applying the method to a synthetic application running within LXC containers on Linux, where a modified kernel has been used that includes our real-time scheduling policy